Coxs Creek is an unincorporated community along U.S. Routes 31E/150 in Nelson County, Kentucky, United States, 4½ miles north of the county seat of Bardstown. It is named for Colonel Isaac Cox of Pennsylvania, who built a "fort" at the site in April 1775 before he fought in the American Revolutionary War, with the help of his brother James. The land had actually been his father's, but David moved back to Virginia before he developed it. More of a station, Cox's 1,000 acres was said to be the first pioneer station in Nelson County. Isaac Cox would later be the last white man to be killed by Indians during the time of the great Indian wars in what later became Kentucky.Kentucky's second Baptist association was formed at Coxs Creek on October 29, 1785. The first post office in the community was established on November 28, 1856, with a descendant of Isaac Cox, John C. Cox, the first postmaster.